1. Making a turn length longer or a drilled hole deeper entails a Z-plus offset on the Swiss-type. (It’s Z-minus on a conventional lathe.)
2. The machining of long parts has to be divided into short segments on the Swiss, because the part can’t be allowed to extend too far from the guide bushing.
3. The size and material of the guide bushing are two important considerations in Swiss machining that don’t exist on a typical CNC lathe.
4. The cutting fluid is usually oil instead of water.
5. Machining cycles are complex and they move very fast.
For more detail, including elaboration on all of the points above, read this article about a shop that implemented its first CNC Swiss-type machine.